Blood Clots Could Be the Root Reason behind All Coronary heart Illness

Editor’s Notice: This text is a reprint. It was initially printed February 13, 2022.

On this interview, repeat visitor Dr. Malcolm Kendrick, a board-certified household doctor and writer of the e-book, “The Clot Thickens: The Enduring Thriller of Coronary heart Illness,” critiques the underlying mechanisms for coronary heart illness, which for the final century has been the main reason behind loss of life within the U.S.

Of all of the books he is written, that is my favourite, because it goes into nice element, providing you with the organic understanding of the method of atherosclerosis resulting in coronary heart assaults and strokes. He additionally has strong methods for decreasing your heart problems danger.

By the way, when you perceive the illness course of, then you may as well perceive how each COVID-19 and the COVID jab can contribute to coronary heart illness. When requested why he is taken such an curiosity in coronary heart illness, Kendrick replies:

“After I was coaching as a pupil in medication, Scotland had the very best fee of coronary heart illness on the earth. Early on the reply for why was, ‘Oh, properly, it is as a result of we’ve such horrible weight loss plan, and we eat garbage meals like deep fried Mars bars.’

So, you eat an excessive amount of saturated fats, the saturated fats will get changed into ldl cholesterol in your bloodstream, after which it is absorbed into arteries and varieties narrowings and thickenings, which all sounds believable should you do not give it some thought too laborious.

However I additionally occur to go to France rather a lot, and what I observed about France was, they eat quite a lot of saturated fats. They eat extra, in truth, than anybody else in Europe, and definitely greater than Scotland. So, [this saturated fat] speculation actually did not work for the French. They’ve the very best saturated fats consumption in Europe and lowest fee of coronary heart illness, and this has been the case for many years.

When you took all the chance elements for France and Scotland [such as smoking, high blood pressure and diabetes], then the French had barely [higher risk], in accordance with typical pondering. However, in truth, they’d one-fifth [the rate among age-matched men].

So, I assumed, that is attention-grabbing. It would not make a lot sense in accordance with what we’re advised. Then whereas I used to be in medical faculty, a tutor in cardiology stated … LDL can not cross the endothelium. On the time, I did not know what LDL was, nor did I do know what the endothelium was, but it surely sounded vital.

She had been taking a look at coronary heart illness as a unique course of for many years … So, I feel that is actually the place I received began. When you begin questioning what the issue is, you find yourself questioning an increasing number of and also you begin pondering, gosh, that is simply nonsense, is not it? This complete speculation is simply nonsense. So, I began selecting it aside.”

The Thrombogenic Speculation

“The Clot Thickens” is Kendrick’s effort to elucidate an alternate speculation for what really causes coronary heart illness. If it isn’t saturated fats and ldl cholesterol, what’s it? In 1852, a Viennese researcher, Karl von Rokitansky, developed what he known as the encrustation speculation of coronary heart illness.

At present, this speculation has been renamed the thrombogenic speculation. “Thrombo” stands for thrombosis, i.e., blood clots, and “genesis” means the reason for, or the beginning of. So, the thrombogenic speculation is that blood clots are the fundamental pathology that causes all coronary heart illness.

In a nutshell, when a blood clot varieties in your artery wall, which may occur for quite a lot of causes, it should sometimes be lined over and dissolved. An issue arises, nonetheless, if the blood clot just isn’t absolutely eradicated and one other blood clot varieties in the identical “weak” space. This then turns into what’s conventionally known as atherosclerotic plaque.

“The atherosclerotic plaque is principally a buildup of blood clot, restore, blood clot, restore, blood clot, restore,” Kendrick explains. “If the blood clotting course of is quicker than the restore course of, you’ve a plaque that step by step grows and ultimately thickens the artery wall till it narrows sufficiently that the ultimate blood clot, on high of the prevailing plaque, is the factor that may trigger a coronary heart assault or stroke …

When you minimize via the plaque and take a look at it, it nearly appears to be like like tree rings. You possibly can see there’s been a clot, restore, clot, restore, clot, restore, clock, restore through the years.

It is extensively accepted {that a} blood clot forming on an present plaque will trigger the plaque to develop in measurement. You will discover 10,000 papers saying that that is the case. What the mainstream will not settle for is {that a} blood clot on a wholesome artery wall can provoke the entire course of.

So, to an extent, all I am saying to folks is, properly, we all know blood clots trigger the ultimate occasion. We all know blood clots trigger plaques to develop. Why will not you settle for that blood clots are the factor that begins it within the first place? As a result of then we’ve one course of during, and it is smart, as a result of it suits with what you possibly can see.”

As famous by Kendrick, the traditional view is that low-density lipoprotein or LDL will get into the artery wall the place it initiates plaque formation. It then, inexplicably, stops initiating plaque, and the plaque continues to develop via the addition of repeated clots.

Nonetheless, Kendrick says, when you begin drilling down into the ldl cholesterol, aka LDL speculation, the entire thing begins to crumble. LDL merely can not clarify the illness development. But regardless of the various holes within the idea, the concept that LDL causes coronary heart illness is touted as an absolute, proven fact.

What is the Mechanism?

As a way to justify a speculation, you have to have a mechanism of motion. When you perceive the mechanism of the particular illness course of, then you possibly can put the puzzle items collectively. Kendrick begins his clarification:

“Your blood vessels are lined with endothelial cells, a bit like tiles on a wall. Endothelial cells are additionally lined themselves in a factor known as glycocalyx. When you attempt to choose up a fish, it will slip via your fingers; it is very slippery. The rationale it is slippery is as a result of it is lined in glycocalyx and the glycocalyx is extremely slippery. It is nature’s Teflon.

So principally, in our case, the glycocalyx [is inside] our blood vessels, to permit the blood to journey via with out it sticking, with out harm occurring. So, you’ve this sort of damage-repellent layer on high of your endothelial cells.

Now, if that layer is broken, after which the endothelial cell itself beneath is broken, then the physique will say, ‘Oh, we have harm to a blood vessel, we will need to have a blood clot there as a result of we might bleed out.’ So, a blood clot varieties on the world of harm, and instantly stops [the bleeding].”

The blood clot would not simply carry on rising and rising. If it did, you’d die anytime you had a blood clot. As a substitute, when a clot varieties, different processes step in to stop it getting too huge, which is why each blood clot would not trigger a stroke or coronary heart assault. As soon as the clot has stabilized, and has been shaved down, the world is roofed over by endothelial progenitor cells, made within the bone marrow, that float round in your blood stream.

When a progenitor cell finds an space that has been broken, it attaches itself to that space, together with others, forming a brand new endothelial layer. The remaining blood clot is now mendacity “inside” the artery wall itself. So, principally, it is the restore course of that may result in plaque buildup inside the artery wall. In time, if harm outstrips restore, this may slim the artery and scale back blood movement.

What Damages Endothelial Cells?

The query is, what can harm the endothelium within the first place? Right here, Kendrick makes use of the SARS-CoV-2 mechanism for example:

“The COVID virus enters endothelial cells via the ACE2 receptor. It prefers endothelial cells as a result of they have ACE2 receptors on them. It will get into the endothelial cell and begins replicating, then bursts out, damaging the cell. Bingo, you have received an space of harm.

After all, added to this, when cells have viruses inside them, they ship out misery indicators to the immune system saying, ‘I have been contaminated, come and kill me,’ and so the immune system begins to have a go on the endothelial cells. Because of this you will get an issue, as a result of the endothelial cells are being broken and stripped off.

Blood clotting happens on the factors of harm and hey, presto, you are having clotting, you are having strokes, you are having coronary heart assaults, which is the factor that folks at first could not perceive [about COVID-19]. But it is very clear that what’s occurring is you have received harm to the endothelial cells.

Clearly, you and I each know that should you get a [COVID jab], the cells are triggered to provide the spike protein, and these cells are sending out misery messages saying, ‘I am contaminated.’ It’s a must to be very cautious if you wish to stick one thing into cells that then says to the immune system, ‘Please come and destroy me,’ as a result of that is what the immune system goes to do.

However shifting on from that, what different factor may cause endothelial harm? The reply is issues like smoking. Smoke particles get out of your lungs, they go into your blood vessels they usually trigger harm … You smoke one cigarette and an entire bunch of microparticles seem in your bloodstream, which implies endothelial cells are dying.

Fortunately as endothelial cells die, one other message is distributed to the bone marrow saying, we’d like extra endothelial cells and it stimulates endothelial progenitor cell manufacturing. These endothelial progenitor cells rush round protecting over the areas of harm.

Some people who smoke have sufficient restore happening and whenever you’re youthful, it is okay. As you become old and your restore methods start to fail a bit, cigarette smoking turns into an increasing number of of an issue.”

Different issues that may trigger endothelial harm embody:

Repairing the Glycocalyx

As defined by Kendrick, the glycocalyx layer resembles a garden, with slippery filaments that stick up. Inside this glycocalyx layer you’ve nitric oxide synthase (NOS), which produces nitric oxide (NO), and you’ve got NO itself, in addition to quite a lot of different anticoagulant proteins. The glycocalyx is definitely a potent anticoagulant layer, so it stops blood clots forming. If glycocalyx is broken, your danger of blood clotting will increase.

“It is a very sophisticated layer,” Kendrick says. “It is like a jungle stuffed with issues that say, ‘Do not stick with this, avoid this.'” Inside it, you even have albumin, protein advanced produced by the liver. Albumin comprises the proteins that assist keep and restore the glycocalyx. A reality that almost all docs are unaware of is that, in case you have a low albumin stage, you are considerably extra more likely to die of coronary heart illness.

The excellent news is that whereas the glycocalyx layer might be quickly destroyed, it may also be quickly repaired. (Experiments have proven that in an space the place the glycocalyx has been utterly stripped off, it may be utterly repaired in a single second.) Dietary supplements like chondroitin sulfate and methylsulfonylmethane (MSM) might be useful on this regard.

“When you attempt to clarify that via the LDL mechanism, it simply would not work,” Kendrick says. “They’ve found that should you give chondroitin sulfate as a complement — which usually is for arthritis and stuff like that — it reduces the chance of coronary heart illness fairly significantly. How do you clarify that? Effectively, you possibly can clarify that since you’re defending your glycocalyx.

These are the type of issues that make no sense should you like wanting on the typical concepts of coronary heart illness, however are instantly and simply defined should you say, ‘We have now to maintain our glycocalyx wholesome and we’ve to maintain our endothelial cells beneath them wholesome.’

In any other case they are going to be broken and stripped off, after which we’ll get a blood clot, and if we hold getting blood clots at that time, we’ll find yourself with a plaque and ultimately one of many blood clots on that plaque will kill you from a coronary heart assault or a stroke.”

Blood Movement Restriction Coaching

A way of life technique that may assist restore endothelial harm is blood movement restriction (BFR) coaching. In response to BFR, your physique produces vascular endothelial development issue (VEGF), which acts as “fertilizer” for the endothelium. You possibly can study the ins and outs of BFR in my free BFR report. VEGF additionally induces the synthesis of nitric oxide (NO), a potent vasodilator, and it stimulates endothelial progenitor cells.

“NO protects the endothelium. It’s anticoagulant — essentially the most potent anticoagulant we’ve within the physique. It is actually the magic molecule for cardiovascular well being,” Kendrick says.

“At one time NO was referred to as Endothelial Derived Leisure Issue (EDRF) NO was one thing nobody believed might presumably exist within the human physique. NO is definitely a free radical. Everybody says free radicals are terribly damaging and unhealthy.

To that I reply, ‘Effectively, you might want to know that the chemical that’s the single most vital protecting chemical within the physique for the cardiovascular system is an extremely free radical known as nitric oxide.'”

Some anticancer medicine are designed to dam VEGF, because the tumor wants angiogenesis — which is the creation of recent blood vessels which can be required to offer ample “vitamins” With out these new blood vessels, the tumor dies off. Sadly, should you block VEGF, you additionally block NO, which then raises your danger for coronary heart illness.

“These medicine have been nearly faraway from the market,” Kendrick says, “as a result of regardless of their anticancer exercise, they have been procardiovascular illness to fairly a scary diploma.

[That’s why], in case you are given bevacizumab or Avastin as an anticancer drug, they now provide you with angiotensin changing enzyme inhibitors (ACE inhibitors), that are blood strain decreasing tablets, and ACE inhibitors have a particular influence on bradykinin, which will increase NO synthesis.”

Methods to Decrease Your Thrombotic Threat

In his e-book, “The Clot Thickens: The Enduring Thriller of Coronary heart Illness,” Kendrick critiques many alternative methods that may decrease your illness danger. Here is a short-list of examples lined in far larger depth within the e-book, in addition to a few of my very own suggestions that I carry up within the interview:

Keep away from pointless use of nonsteroidal anti-inflammatories (NSAIDs) corresponding to ibuprofen and naproxen — Whereas they successfully inhibit irritation, they will trigger platelet aggregation by blocking COX-2. In different phrases, they activate your blood clotting system, making blood clots extra doubtless.

Get loads of smart solar publicity — Solar publicity triggers NO that helps dilate your blood vessels, decreasing your blood strain. NO additionally protects your endothelium, and will increase mitochondrial melatonin to enhance mobile vitality manufacturing.

Keep away from seed oils and processed meals — Seed oils are a main supply of the omega-6 fats known as linoleic acid (LA), which I consider could also be much more dangerous than sugar. Extreme consumption is related to most all power illnesses, together with hypertension, weight problems, insulin resistance and diabetes. LA will get embedded in your cell membranes, inflicting oxidative stress, and may stay there for as much as seven years. Oxidative linoleic acid metabolites (OXLAMs) are what’s inflicting the first harm, together with endothelial harm.

Decrease your insulin and blood sugar ranges — Easy methods to perform this embody, avoiding ultraprocessed meals and synthetic sweeteners, considerably proscribing your LA consumption and getting common train.

Deal with power stress, which raises each blood sugar and blood strain, promotes blood clotting and impairs your restore methods. Cortisol, a key stress hormone, reduces endothelial cell manufacturing.

Stop smoking.